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Diseases in the IEDB

Ward Fleri
posted this on August 09, 2012 11:49 PM

The IEDB contains experimental epitope related data relevant to infectious diseases, allergy, autoimmunity, and transplant.  The disease state of the host at the time of the assay is described and searchable.  Users can easily narrow their search results by the higher levels of the tree such as Autoimmune Disease or Allergic Disease.

For more specific disease states, one can search or browse the Disease tree, a hierarchical tree that organizes the data at the highest level according to the five disease categories (Allergy, Autoimmunity, Infectious Disease, Transplant-related Disease and Allo-reactivity, and Additional Diseases by category), and then by the anatomical location of the disease (e.g. respiratory tract, gastrointestinal tract). 

In this way the user can either type in the disease name or synonym (including ICD10 codes) of interest, or navigate the Disease Tree by disease manifestation and physical location to see what is available.  A node for healthy subjects is also included.  In the future, there are plans to implement the ability for the user to search for disease association by the epitope source antigen that has been computationally associated with a specified disease.  Currently, Disease Association is functional for Allergy and Autoimmunity.  Its functionality will be expanded in the future to include transplant-related diseases and an improved categorization of allergic diseases.  Infectious disease searches are well accommodated by the Source Organism Finder.

The user can search for terms using the Find box at the top of the Disease Finder.  In the example shown in Figure 1, rheumatoid arthritis has been entered.  When the Search button is clicked, the Disease Finder returns 5 records, as shown.  If the user clicks the Highlight in Tree next to rheumatoid arthritis, the system will expand the Disease Tree and highlight the selection, as shown in Figures 2.  DOID refers to the Disease Ontology identifier.  The DTREE designates an IEDB-specific identifier that will be updated later with a DOID number when the Disease Ontology incorporates the terms.  A mouse-over balloon provides additional information on each node of the tree, as shown in the figure.

diseaseFinderTopRA.PNG

Figure 1.  The Disease Finder returns 5 items when a search for "rheumatoid arthritis" is performed

 

diseaseTreeRA.png

Figures 2.  The disease finder within the Immune Mediated Disease Association section of the Home Page search with rheumatoid arthritis highlighted

 
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