This query feature allows users to select a disease association based on the host disease state or status as captured in curation. Diseases are organized into a browsable tree structure. Upon the selection of host disease state/status, the system provides the user with a hierarchical Disease Tree that organizes the data at the highest level according to the five disease categories (Allergy, Autoimmunity, Infectious Disease, Additional Diseases by category, and Transplant-related Disease and Allo-reactivity) and then by the anatomical location of the disease (e.g. respiratory tract, gastrointestinal tract). In this way the user can either type in the disease name or synonym of interest, or navigate the Disease Tree by disease manifestation and physical location to see what is available. A node for healthy subjects is also included. The Disease Finder is fully functional for only Autoimmunity. The finder will be revised with an updated disease ontology and hierarchical tree during 2015 that will make it functional for the other disease categories. Infectious disease searches are best accommodated using the Organism Finder to specify the antigen.
Figure 1 shows the Disease Tree with diabetes highlighted. DOID refers to the Disease Ontology identifier. The DTREE designates an IEDB-specific identifier that will be updated later with a DOID number when the Disease Ontology incorporates the terms.
Figure 1. The Disease Finder returns 4 items when a search for "diabetes" is performed