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  1. IEDB Solutions Center
  2. General
  3. Frequently Asked Questions (FAQ)

Frequently Asked Questions (FAQ)

Answers to common user inquiries

  • What is the difference between the 'curated' and 'calculated' receptor sequence information?
  • What allele types can I select for my MHC Class I and Class II predictions?
  • What does positive high / intermediate / low mean in the assay description column?
  • What does 'Dual' mean in the details of the 'Reference' tab?
  • Questions About the Data in the IEDB
  • Data Export
  • Help with Querying (IEDB 3.0)
  • Recommended Browsers
  • What is the rate limit for requesting information from the API (e.g. I can make X requests per second/minute)?
  • I have a particular MHC class I or II allele for which I want to run binding predictions but it does not show up on the list. How can I make such predictions?
  • Finding cross reactive epitopes between humans and pathogens
  • What thresholds (cut-offs) should I use for MHC class I and II binding predictions
  • Why do I get an error message when I run the class I or II binding tools?
  • Searching for H1N1 epitopes from Hemagglutinin
  • How do I retrieve peptides that bind to a specific MHC allele along with their measured IC50 binding affinities?
  • How do I generate a list of all MHC alleles that have been reported to present epitopes from an organism of interest? Can I select a specific host?
  • Is it possible to generate a list of epitopes identified as cross-reactive against different strains of the same species? Can I look at reactivity across genera?
  • How do I generate data for all epitopes that have been associated with in vitro correlates of protection (virus neutralization, CTL, inhibition of infectivity, etc.)? Can I search by the type of assay?
  • How do I generate data for all epitopes that have been identified as protective in vivo (epitope used to immunize prior to live challenge) against the organism of interest?
  • How do I generate data for all epitopes that have been identified following natural infection or experimental immunization in humans with respect to the organism of interest?
  • How do I generate data for all epitopes that have been reported for a specific human disease associated with a organism of interest?
  • How do I generate data for all host species in which immune responses defining epitopes have been reported for an organism of interest?
  • How do I generate a list of all proteins from which epitopes have been identified for an organism of interest?
  • How do I generate a list of all the different species and strains reported for an organism of interest?
  • How do I find out the total number of B cell/antibody epitopes reported for an organism of interest? How do I then determine the number of linear versus conformational epitopes?
  • How do I find out the total number of T cell epitopes reported for an organism of interest? How do I then determine the total number of CD4 versus CD8 epitopes?
  • How do I determine the total number of epitopes reported for an organism of interest, including the breakdown of peptidic versus non-peptidic structures, as well as the number of positive and negative?
  • How to do I determine the origin of the IEDB epitope data (PubMed ID or direct submission) for an organism of interest?
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