A molecular view of multiple sclerosis and experimental autoimmune encephalitis: What can we learn from the epitope data? (2013)

Vaughan K, Peters B, O'Connor KC, Martin R, Sette A. A molecular view of multiple sclerosis and experimental autoimmune encephalitis: What can we learn from the epitope data? J Neuroimmunol. 2013 Dec 12. pii: S0165-5728(13)00340-8. doi: 10.1016/j.jneuroim.2013.12.009. PubMed PMID: 24365494

An analysis to inventory all immune epitope data related to multiple sclerosis (MS) was performed using the Immune Epitope Database (IEDB). The analysis revealed that MS related data represent >20% of all autoimmune data, and that studies of EAE predominate; only 22% of the references describe human data. To date, >5800 unique peptides, analogs, mimotopes, and/or non-protein epitopes have been reported from 861 references, including data describing myelin-containing, as well as non-myelin antigens. This work provides a reference point for the scientific community of the universe of available data for MS-related adaptive immunity in the context of EAE and human disease.