Next-Generation IEDB Tools Website and API - Release 1.0

We are excited to announce that the initial release of the Next-Generation IEDB Tools Website is now open to the public!  This is a complete redesign of the IEDB Analysis Resource with an emphasis on usability, simplicity, and tool integration.

Head over to https://nextgen-tools.iedb.org/ to try it out!

Release notes - 1.0 (Feb 14, 2023)

• Streamlined and consistent user interface with tools for power users
• Pipelines allow for chaining together various tools in a single run
• Available tools:
  • T cell class I application includes most tools related to MHC class I epitope prediction and analysis and allows the running of multiple tools simultaneously
    • MHC-I binding
    • MHC-I processing
    • MHC-I immunogenicity
  • Clustering provides a way to group peptide sequences based on sequence identity
  • PEPMatch allows for the efficient search for closely related peptides in several common reference proteomes
• New API to support pipelining and predictions for large datasets
• New, rich user documentation is available at https://nextgen-tools.iedb.org/docs/
• Follow-up releases planned on a 3-month cycle
  • Next release will focus on enhancing speed
• Additional tools will be migrated from the legacy site (https://tools.iedb.org) over the next iterations

Release notes - 1.0.1 (Jun 2, 2023)

• PEPMatch updated to version 0.8.3
  • Peptides with 0 matches are no longer shown in the output
• Pipeline map updated to include 'Run' button and make controls for adding steps more intuitive
• Resource limits implemented on several tools to prevent server overload
• Several new conditions tested to provide users with meaningful warning and error messages

Release notes - 1.0.2 (Jun 15, 2023)

• bug fixed in smm & smmpmbec IC50 and percentile calculations for lengths other than 9
• backend API functionality enhancements and stability improvements

Release notes - 1.0.3 (Jun 20, 2023)

• bug fixed in immunogenicity tool for 'custom' and 'by allele' options