General
General Announcements and Updates
Analysis Tools
Common Queries
- How do I generate a list of all MHC alleles that have been reported to present epitopes from an organism of interest? Can I select a specific host?
- If I want to drill down into the data presented by the Search Result Summary, what is the best approach?
- How do I add different elements or criteria to my query?
- Is it possible to generate a list of epitopes identified as cross-reactive against different strains of the same species? Can I look at reactivity across genera?
- How do I generate data for all epitopes that have been associated with in vitro correlates of protection (virus neutralization, CTL, inhibition of infectivity, etc.)? Can I search by the type of assay?
- How do I generate data for all epitopes that have been identified as protective in vivo (epitope used to immunize prior to live challenge) against the organism of interest?
Annual Compendia & System Architecture and Design
- IEDB Annual Compendium for 2016
- IEDB System Architecture and Design
- IEDB Annual Compendium for 2015
- IEDB Annual Compendium for 2014
- IEDB Annual Compendium for 2013
- IEDB Annual Compendium for 2012
Data Submissions
Developer's Page
- IEDB Ontology
- Announcement Regarding HLA Nomenclature in the Immune Epitope Database (IEDB)
- XML Schema Update Announced (7 Dec 2009)
- XML Schema Update Announced (25 September 2009)
- IEDB Database Exports (XML/SQL/CSV)
- IEDB LinkOut
Meta-Analyses
- Identifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus Species (2016)
- Ebola: an analysis of immunity at the molecular level (2015)
- Analysis of Human RSV Immunity at the Molecular Level: Learning from the Past and Present (2015)
- The Use of the Immune Epitope Database to Study Autoimmune Epitope Data Related to Alopecia Areata (2015)
- Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy (2014)
- Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks (2014)
New and Noteworthy
Newsletters - Archive
- August 2012 Newsletter
- May 2012 Newsletter
- October 2011 Newsletter
- August 2011 Newsletter
- May 2011 Newsletter
- February 2011 Newsletter
Prediction Tools
- MHC class I binding prediction - Internal Server Error
- MHC II Epitope Prediction - "Internal Server Error"
- When can I consider an epitope as non-binder using MHC class I and II binding predictions tools?
- anchor residues
- HLA allele frequencies and reference sets with maximal population coverage
- HLA nomenclature
Publications
- The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design (2017)
- Better living through ontologies at the Immune Epitope Database (2017)
- Breaking confinement: unconventional peptide presentation by major histocompatibility (MHC) class I allele HLA-A*02:01 (2017)
- Identifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus Species (2016)
- Immune Epitope Database and Analysis Resource (2016)
- TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates (2016)
Queries and Reporting
- Finding cross reactive epitopes between humans and pathogens
- Searching for H1N1 epitopes from Hemagglutinin
- How do I retrieve peptides that bind to a specific MHC allele along with their measured IC50 binding affinities?
- Select all MHC binding assays for class II human epitopes with a SQL query
- mhc class I, class II binders/ non-binders
- Query for epitope within a longer sequence
Release Notes
- IEDB Analysis Resource v2.19 release notes (25 Apr 2018)
- IEDB v3.6.0 Release Notes (16 December 2016)
- IEDB 3.3 Release Notes (5 February 2016)
- IEDB v3.9.0 Release Notes
- IEDB v3.8.0 Release Notes
- IEDB v3.7.0 Release Notes
Tutorials and Reference Materials
- IEDB User Documentation Release 3
- How-To Videos
- 2017 IEDB User Workshop Presentations
- 2015 IEDB User Workshop Presentations
- Browse by Source Organism (IEDB 3.0)
- Browse by MHC Allele (IEDB 3.0)
Upcoming Events
Web Browser Related Topics
Workshop Reports
Frequently Asked Questions (FAQ)
- What is the rate limit for requesting information from the API (e.g. I can make X requests per second/minute)?
- I have a particular MHC class I or II allele for which I want to run binding predictions but it does not show up on the list. How can I make such predictions?
- Why does the MHC class II binding prediction operate only on 15-mers?
- What thresholds (cut-offs) should I use for MHC class I and II binding predictions
- Why do I get an error message when I run the class I or II binding tools?