IEDB Analysis Resource v2.27 release notes (25 May 2023)

Major updates:

• New tool: Peptide eXpression annotator (pepX) helps to estimate tissue-specific peptide abundance from public RNA-Seq data
• NetMHCIIpan 4.1 has been incorporated into the MHC II binding prediction tool and has become the 'IEDB Recommended' method
• TCRMatch updated to version 1.1.1 to allow for TRUST4-formatted input
• AxelF updated to allow for more flexible input and to support the output of pepX as input for the tool

Many bug fixes and performance improvements have been incorporated in point releases since v2.26, including:

• New tool: PepSySco to predict success of peptide synthesis
• New servers incorporated into automated server benchmarks: NetMHCpan 4.1, NN-align 2.3, NetMHCIIpan 3.2, NetMHCIIpan 4.0
• Bugfix: Population Coverage tool updated to deal with quoted allele names
• Bugfix: BepiPred 2.0 results correctly formatted
• Bugfix: error when IC50 is used as a threshold in Tepitool for MHC II
• Bugfix: missing percentile data for 22 HLA alleles added to NetMHCcons

Minor releases since 2.27:

v2.27.1

• PepX tool released and available on IEDB Tools

v2.27.2

• Enable Trust4 input for the TCRMatch tool

v2.27.3

• 6 mouse alleles were added for NetMHCIIpan 4.0 & 4.1

v2.27.4

• Additional reference added for NetMHCIIpan 4.1

v2.27.5

• NetMHCpan method was removed from MHC-NP

v2.27.6

• Bugfix for MHC-NP to accept multiple alleles and lengths

v2.27.7

• mhci & mhcii recommended methods adjustment
• NetMHCpan EL and NetMHCIIpan EL added to automated benchmarks

v2.27.8

• Add 4 alleles for NetMHCpan 4.1 (EL & BA): 'H-2-Dq', 'H-2-Kq', 'H-2-Lq', 'SLA-3*0402'
• Tepitool download result table has been fixed for the MHCII IEDB recommended method
• Tepitool result table corrected to display and sort by median percentile rank