Release 4.1 of the Next-Generation IEDB Tools Website is now live! This release introduces several incremental improvements to exiting tools, in order to enable more sophisticated pipeline functionality in the future.
Head over to https://nextgen-tools.iedb.org/ to try it out!
Release notes - 4.1 (Apr 21, 2026)
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Usability improvements
- Option added to PepX to include output for unmatched peptides
- Mutated Peptide Generator parameter validation updates
- Additional columns added to Mutated Peptide Generator output to denote peptide lengths
- Linear epitope table of B cell sequence & structure tools added an average score for each method, regardless of the method that identified the epitope
- Additional columns added to MHCflurry output
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Clarity improvements
- B cell tools renamed to reference the type of input they accept
- Relative percentile rank definitions for B cell tools updated
- Documentation layout reorganized into tool group sections
- NetCTL & NetCTLpan labeled with 'historic' badge
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Stability improvements
- More detailed logging enabled on the backend to help the team more rapidly debug issues
- Aggregation of NetCTL and NetCTLpan output with binding data is fixed
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